Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. [electronic resource]
Producer: 20040630Description: 21695-700 p. digitalISSN:- 0021-9258
- Androstadienes -- pharmacology
- Animals
- Chromones -- pharmacology
- Diet
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Insulin Resistance
- Leptin -- metabolism
- Lipid Metabolism
- Liver -- enzymology
- Male
- Morpholines -- pharmacology
- Obesity -- enzymology
- Oxygen Consumption
- Perfusion
- Phosphatidylinositol 3-Kinases -- chemistry
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Quinolones -- pharmacology
- Rats
- Rats, Wistar
- Serine -- chemistry
- Time Factors
- Triglycerides -- metabolism
- Wortmannin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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