Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. [electronic resource]
Producer: 20040615Description: 19683-90 p. digitalISSN:- 0021-9258
- Androstadienes -- pharmacology
- Animals
- Blotting, Western
- Carcinoma, Lewis Lung -- metabolism
- Cell Line, Tumor
- Chloramphenicol O-Acetyltransferase -- metabolism
- Chromones -- pharmacology
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Extracellular Matrix -- metabolism
- Flavonoids -- pharmacology
- Gene Expression Regulation, Enzymologic
- Genes, Dominant
- Genes, Reporter
- Insulin-Like Growth Factor I -- metabolism
- Matrix Metalloproteinase 2 -- biosynthesis
- Mice
- Mitogen-Activated Protein Kinases -- metabolism
- Models, Biological
- Morpholines -- pharmacology
- PTEN Phosphohydrolase
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoric Monoester Hydrolases -- metabolism
- Plasmids -- metabolism
- Proto-Oncogene Proteins c-raf -- metabolism
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Sirolimus -- metabolism
- Time Factors
- Tumor Suppressor Proteins -- metabolism
- Wortmannin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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