Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen. [electronic resource]
Producer: 20040930Description: 321-7 p. digitalISSN:- 0090-9556
- Animals
- Antimetabolites, Antineoplastic -- chemistry
- Cell Line, Tumor
- Databases, Genetic
- Drug Screening Assays, Antitumor
- Glutathione -- metabolism
- Humans
- Lethal Dose 50
- Mercaptopurine -- chemistry
- National Institutes of Health (U.S.)
- Prodrugs -- chemistry
- Purines -- chemistry
- Rats
- Stereoisomerism
- Thioguanine -- chemistry
- United States
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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