Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR. [electronic resource]
Producer: 20041026Description: 273-82 p. digitalISSN:- 1470-8728
- Alleles
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal -- immunology
- Circular Dichroism
- Copper -- pharmacology
- Drug Resistance
- Endopeptidase K -- pharmacology
- Genetic Predisposition to Disease
- Immunity, Innate
- Manganese -- pharmacology
- Mice
- Mice, Knockout
- Nickel -- pharmacology
- Peptide Fragments -- immunology
- Polymorphism, Genetic
- PrPC Proteins -- chemistry
- Protein Denaturation
- Protein Folding
- Protein Structure, Secondary -- drug effects
- Recombinant Fusion Proteins -- chemistry
- Scrapie -- genetics
- Sheep -- genetics
- Sheep Diseases -- genetics
- Temperature
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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