Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis. [electronic resource]
Producer: 20040324Description: 336-47 p. digitalISSN:- 0020-7136
- Cell Division -- drug effects
- Down-Regulation -- drug effects
- Enzyme Activation
- Female
- Humans
- Insulin-Like Growth Factor Binding Protein 4 -- metabolism
- Insulin-Like Growth Factor I -- pharmacology
- MAP Kinase Signaling System
- Membrane Glycoproteins -- pharmacology
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases -- metabolism
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Oligonucleotides, Antisense -- pharmacology
- Ovarian Neoplasms -- metabolism
- Pregnancy-Associated Plasma Protein-A -- genetics
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- RNA, Messenger -- metabolism
- Serine Proteinase Inhibitors -- pharmacology
- Trypsin Inhibitor, Kunitz Soybean -- pharmacology
- Tumor Cells, Cultured
- Urokinase-Type Plasminogen Activator -- genetics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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