Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. [electronic resource]
Producer: 20040401Description: 252-61 p. digitalISSN:- 0008-5472
- Animals
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Monitoring -- methods
- Everolimus
- Humans
- Immunosuppressive Agents -- administration & dosage
- Leukocytes, Mononuclear -- enzymology
- MAP Kinase Signaling System -- drug effects
- Male
- Pancreatic Neoplasms -- drug therapy
- Rats
- Rats, Inbred Lew
- Ribosomal Protein S6 Kinases, 90-kDa -- antagonists & inhibitors
- Sirolimus -- administration & dosage
- Time Factors
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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