Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. [electronic resource]
Producer: 20040521Description: 525-33 p. digitalISSN:- 1524-4571
- Adenosine Triphosphate -- biosynthesis
- Age Factors
- Animals
- Animals, Newborn
- Cardiomyopathy, Dilated -- genetics
- Disease Models, Animal
- Doxycycline -- pharmacology
- Energy Metabolism
- Gene Expression Regulation, Developmental -- drug effects
- Genes, Synthetic
- Mice
- Mice, Transgenic
- Mitochondria, Heart -- physiology
- Myocytes, Cardiac -- metabolism
- Myosin Heavy Chains -- genetics
- Organ Specificity
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Promoter Regions, Genetic -- genetics
- Recombinant Fusion Proteins -- physiology
- Regulatory Sequences, Nucleic Acid -- drug effects
- Trans-Activators -- biosynthesis
- Transcription Factors
- Transgenes
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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