Ebselen inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38 MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2. [electronic resource]
Producer: 20040126Description: 1345-53 p. digitalISSN:- 0022-3042
- Animals
- Annexin A5 -- metabolism
- Apoptosis
- Azoles -- pharmacology
- Blotting, Western
- Butadienes -- pharmacology
- Caspase 3
- Caspases -- metabolism
- Cell Differentiation -- drug effects
- Cell Survival -- drug effects
- Chaperonin 60 -- metabolism
- Cyclooxygenase Inhibitors -- pharmacology
- Cytochromes c -- metabolism
- Dithiothreitol -- pharmacology
- Dose-Response Relationship, Drug
- Drug Interactions
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- In Vitro Techniques
- Isoindoles
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase Kinase 5
- MAP Kinase Kinase Kinases -- metabolism
- Mitogen-Activated Protein Kinases -- metabolism
- Nerve Growth Factor -- pharmacology
- Nitric Oxide -- metabolism
- Nitric Oxide Donors -- pharmacology
- Nitriles -- pharmacology
- Nitroprusside -- pharmacology
- Organoselenium Compounds -- pharmacology
- PC12 Cells
- Propidium -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Rats
- Serine -- metabolism
- Sodium Selenite -- pharmacology
- Time Factors
- Transfection
- Tumor Suppressor Protein p53 -- metabolism
- Vitamin E -- pharmacology
- p38 Mitogen-Activated Protein Kinases
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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