Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). [electronic resource]
Producer: 20040212Description: 1-12 p. digitalISSN:- 0090-3493
- Adult
- Aged
- Aged, 80 and over
- Critical Care -- methods
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Hemodynamics -- drug effects
- Humans
- Infusions, Intravenous
- Intensive Care Units
- Male
- Middle Aged
- Nitric Oxide Synthase -- antagonists & inhibitors
- Oxygen Consumption -- drug effects
- Probability
- Reference Values
- Risk Assessment
- Severity of Illness Index
- Shock, Septic -- drug therapy
- Survival Analysis
- Treatment Outcome
- omega-N-Methylarginine -- administration & dosage
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Publication Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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