G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. [electronic resource]
Producer: 20040209Description: 399-405 p. digitalISSN:- 1524-4539
- Cells, Cultured
- Endothelium, Vascular -- cytology
- Gene Expression Regulation, Enzymologic
- Humans
- Insulin -- pharmacology
- Insulin Receptor Substrate Proteins
- Mitogen-Activated Protein Kinases -- metabolism
- Nitric Oxide Synthase -- genetics
- Nitric Oxide Synthase Type III
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoproteins -- genetics
- Phosphorylation -- drug effects
- Polymorphism, Genetic
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- RNA, Messenger -- metabolism
- Signal Transduction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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