Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. [electronic resource]
Producer: 20040220Description: 250-61 p. digitalISSN:- 0066-4804
- Algorithms
- Amidohydrolases -- antagonists & inhibitors
- Animals
- Anti-Infective Agents -- chemical synthesis
- Antineoplastic Agents -- chemical synthesis
- Binding Sites
- Cell Line, Tumor
- Chelating Agents -- chemistry
- Combinatorial Chemistry Techniques
- Drug Design
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- Escherichia coli -- drug effects
- Female
- Half-Life
- Humans
- Hydroxamic Acids -- chemical synthesis
- Lethal Dose 50
- Mice
- Models, Molecular
- Peptide Library
- Proline -- analogs & derivatives
- Sepsis -- drug therapy
- Structure-Activity Relationship
- Tissue Distribution
- X-Ray Diffraction
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Publication Type: Journal Article
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