Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis. [electronic resource]
Producer: 20040527Description: 1024-33 p. digitalISSN:- 1091-255X
- Adenocarcinoma -- drug therapy
- Apoptosis -- drug effects
- Butadienes -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Cell Cycle -- drug effects
- Cell Division -- drug effects
- Cell Line, Tumor
- Cyclooxygenase 1
- Cyclooxygenase 2
- Dinoprostone -- metabolism
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Humans
- Isoenzymes -- antagonists & inhibitors
- Liver Neoplasms -- drug therapy
- Membrane Proteins
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Mitogen-Activated Protein Kinases -- drug effects
- Nitriles -- pharmacology
- Nitrobenzenes -- pharmacology
- Pancreatic Neoplasms -- drug therapy
- Prostaglandin-Endoperoxide Synthases -- drug effects
- Signal Transduction -- drug effects
- Sulfonamides -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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