Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. [electronic resource]
Producer: 20040315Description: 6929-35 p. digitalISSN:- 0022-1767
- Animals
- Antibodies, Monoclonal -- administration & dosage
- Antigens, Surface -- physiology
- Apoptosis Regulatory Proteins
- B7-1 Antigen
- B7-H1 Antigen
- Blood Proteins -- antagonists & inhibitors
- Cell Differentiation -- genetics
- Cell Division -- genetics
- Chemokine CCL2 -- antagonists & inhibitors
- Clone Cells
- Dose-Response Relationship, Immunologic
- Female
- Graft Enhancement, Immunologic -- methods
- Graft Rejection -- immunology
- Graft Survival -- drug effects
- Islets of Langerhans Transplantation -- immunology
- Ligands
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Organ Culture Techniques
- Peptides -- antagonists & inhibitors
- Programmed Cell Death 1 Receptor
- Proteins -- metabolism
- Receptors, CCR2
- Receptors, Chemokine -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Sirolimus -- administration & dosage
- T-Lymphocyte Subsets -- cytology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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