Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells. [electronic resource]
Producer: 20040123Description: 464-72 p. digitalISSN:- 0020-7136
- Animals
- Apoptosis -- drug effects
- Camptothecin -- analogs & derivatives
- Cell Division -- drug effects
- Colorectal Neoplasms -- drug therapy
- DNA Topoisomerases, Type I -- genetics
- Drug Interactions
- Drug Synergism
- Drug Therapy, Combination
- Enzyme Inhibitors -- therapeutic use
- ErbB Receptors -- antagonists & inhibitors
- Female
- Gefitinib
- Humans
- Irinotecan
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phosphorylation
- Poly(ADP-ribose) Polymerases -- metabolism
- Quinazolines -- therapeutic use
- RNA, Messenger -- metabolism
- Receptor, ErbB-2 -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Topoisomerase I Inhibitors
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Comparative Study; Journal Article
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