Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity. [electronic resource]
Producer: 20040113Description: 13194-202 p. digitalISSN:- 0022-538X
- Anaphase-Promoting Complex-Cyclosome
- Animals
- Brain Diseases -- virology
- Cell Line
- Cyclin D1 -- metabolism
- Cyclin D3
- Cyclins -- metabolism
- Gene Deletion
- Herpes Simplex -- virology
- Herpesvirus 1, Human -- genetics
- Humans
- Immediate-Early Proteins -- genetics
- Mice
- Mice, Inbred CBA
- Mutation
- Ubiquitin-Conjugating Enzymes
- Ubiquitin-Protein Ligase Complexes -- metabolism
- Ubiquitin-Protein Ligases -- genetics
- Virulence
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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