B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts. [electronic resource]
Producer: 20040519Description: 609-16 p. digitalISSN:- 1470-8728
- Binding Sites
- CCAAT-Binding Factor -- metabolism
- Cell Cycle Proteins
- Cell Line
- Cell Nucleus -- metabolism
- Collagen Type I -- genetics
- Collagen Type I, alpha 1 Chain
- DNA-Binding Proteins -- chemistry
- Dermis -- cytology
- Down-Regulation
- Female
- Fibroblasts -- metabolism
- Gene Silencing
- Humans
- Macromolecular Substances
- Male
- Promoter Regions, Genetic
- Protein Structure, Tertiary
- Repressor Proteins -- metabolism
- Scleroderma, Systemic -- genetics
- Sp1 Transcription Factor -- metabolism
- Trans-Activators -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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