Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. [electronic resource]
Producer: 20031219Description: 393-405 p. digitalISSN:- 0360-4012
- Alzheimer Disease -- genetics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides -- metabolism
- Animals
- Aspartic Acid Endopeptidases -- metabolism
- Cells, Cultured
- Chromaffin Cells -- drug effects
- Cysteine Endopeptidases -- metabolism
- Cysteine Proteinase Inhibitors -- pharmacology
- Dithiothreitol -- pharmacology
- Endopeptidases -- metabolism
- Extracellular Space -- metabolism
- Glutathione -- pharmacology
- Leucine -- analogs & derivatives
- Mice
- Mice, Knockout
- Mutation
- Neurons -- drug effects
- Nicotine -- pharmacology
- Nicotinic Agonists -- pharmacology
- Peptide Fragments -- metabolism
- Potassium Chloride -- pharmacology
- Secretory Vesicles -- metabolism
- Substrate Specificity
- Time Factors
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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