Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death. [electronic resource]
Producer: 20031216Description: 309-17 p. digitalISSN:- 0360-4012
- Animals
- Caspase 3
- Caspases -- metabolism
- Cell Death -- drug effects
- Cell Membrane Permeability -- drug effects
- Chromatin -- drug effects
- Cyclosporine -- pharmacology
- Cytochromes c -- metabolism
- Ion Channels -- antagonists & inhibitors
- Keto Acids -- pharmacology
- Ketoglutarate Dehydrogenase Complex -- antagonists & inhibitors
- L-Lactate Dehydrogenase -- metabolism
- Matrix Metalloproteinases -- drug effects
- Membrane Potentials -- drug effects
- Mitochondria -- drug effects
- Mitochondrial Membrane Transport Proteins
- Mitochondrial Permeability Transition Pore
- Necrosis
- Neurodegenerative Diseases -- enzymology
- Neurons -- drug effects
- PC12 Cells
- Protein Transport -- drug effects
- Rats
- Reactive Oxygen Species -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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