Pharmacokinetics of a novel N-methyl-D-aspartate receptor antagonist (SM-18400): identification of an N-acetylated metabolite and pre-clinical assessment of N-acetylation polymorphism. [electronic resource]
Producer: 20031006Description: 21-9 p. digitalISSN:- 0378-7966
- Acetylation
- Acetyltransferases -- metabolism
- Animals
- Area Under Curve
- Biotransformation
- Chromatography, High Pressure Liquid
- Cytosol -- metabolism
- Dogs
- Excitatory Amino Acid Antagonists -- pharmacokinetics
- Humans
- In Vitro Techniques
- Indicators and Reagents
- Kinetics
- Liver -- metabolism
- Male
- Polymorphism, Genetic
- Quinoxalines -- pharmacokinetics
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors
- Spectrometry, Mass, Electrospray Ionization
- Subcellular Fractions -- metabolism
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Publication Type: Journal Article
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