Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. [electronic resource]
Producer: 20031031Description: 6231-42 p. digitalISSN:- 0950-9232
- Apoptosis -- drug effects
- Benzamides -- pharmacology
- Butyrates -- pharmacology
- Chromones -- pharmacology
- Complement Membrane Attack Complex
- Complement System Proteins
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins -- metabolism
- Cytochrome c Group -- drug effects
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Glycoproteins -- drug effects
- HL-60 Cells
- Histone Deacetylase Inhibitors
- Humans
- Jurkat Cells
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- enzymology
- Mitochondria -- drug effects
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinases -- metabolism
- Morpholines -- pharmacology
- Phosphoinositide-3 Kinase Inhibitors
- Plant Proteins
- Pyridines -- pharmacology
- U937 Cells
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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