Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. [electronic resource]
Producer: 19920528Description: 8577-83 p. digitalISSN:- 0021-9258
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase -- genetics
- 5-alpha Reductase Inhibitors
- Amino Acid Sequence
- Androstenes -- pharmacology
- Animals
- Azasteroids -- pharmacology
- Binding, Competitive
- Blotting, Western
- Cells, Cultured
- DNA -- genetics
- Finasteride
- Humans
- Isoenzymes -- antagonists & inhibitors
- Kidney -- cytology
- Kinetics
- Molecular Sequence Data
- Rats
- Recombinant Fusion Proteins -- antagonists & inhibitors
- Sequence Alignment
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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