E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. [electronic resource]
Producer: 20031023Description: 6542-52 p. digitalISSN:- 0270-7306
- Animals
- Animals, Newborn
- Carcinoma, Medullary -- etiology
- E2F3 Transcription Factor
- Female
- Fetal Viability -- genetics
- Gene Dosage
- Heterozygote
- Longevity
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Neoplasm Metastasis -- genetics
- Phenotype
- Pituitary Neoplasms -- genetics
- Retinoblastoma Protein -- deficiency
- Thyroid Neoplasms -- etiology
- Transcription Factors -- deficiency
- Tumor Suppressor Protein p53
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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