Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. [electronic resource]
Producer: 20030924Description: 5126-35 p. digitalISSN:- 0008-5472
- Acetylation
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzamides
- Blast Crisis -- drug therapy
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins -- biosynthesis
- Cysteine Endopeptidases -- physiology
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- pharmacology
- Fusion Proteins, bcr-abl -- genetics
- G1 Phase -- drug effects
- Histone Deacetylase Inhibitors
- Humans
- Hydroxamic Acids -- pharmacology
- Imatinib Mesylate
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Microfilament Proteins -- biosynthesis
- Multienzyme Complexes -- physiology
- Muscle Proteins
- Piperazines -- pharmacology
- Promoter Regions, Genetic
- Proteasome Endopeptidase Complex
- Pyridones -- pharmacology
- Pyrimidines -- pharmacology
- Tumor Cells, Cultured
No physical items for this record
Publication Type: Journal Article
There are no comments on this title.
Log in to your account to post a comment.