A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. [electronic resource]
Producer: 20031224Description: 42821-8 p. digitalISSN:- 0021-9258
- Adjuvants, Anesthesia -- pharmacology
- Allosteric Site
- Amino Acid Sequence
- Anesthetics -- pharmacology
- Anesthetics, Intravenous -- pharmacology
- Animals
- Cloning, Molecular
- DNA Mutational Analysis
- Dose-Response Relationship, Drug
- Etomidate -- pharmacology
- Kinetics
- Ligands
- Models, Biological
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Oocytes -- metabolism
- Patch-Clamp Techniques
- Pentobarbital -- pharmacology
- Point Mutation
- Pregnanediones -- pharmacology
- Propofol -- pharmacology
- Protein Structure, Tertiary
- RNA, Messenger -- metabolism
- Rats
- Receptors, GABA-A -- chemistry
- Recombinant Proteins -- metabolism
- Xenopus
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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