Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. [electronic resource]
Producer: 20031003Description: 1238-45 p. digitalISSN:- 1524-4539
- Acetophenones -- therapeutic use
- Animals
- Antioxidants -- therapeutic use
- Atrasentan
- Biopterins -- analogs & derivatives
- Carotid Arteries -- drug effects
- Cyclic N-Oxides -- therapeutic use
- Desoxycorticosterone
- Disease Models, Animal
- Endothelin Receptor Antagonists
- Endothelin-1 -- pharmacology
- Endothelium, Vascular -- drug effects
- Enzyme Inhibitors -- pharmacology
- GTP Cyclohydrolase -- genetics
- Gene Transfer Techniques
- Genetic Therapy -- methods
- Humans
- Hypertension -- chemically induced
- In Vitro Techniques
- Male
- Nitric Oxide -- metabolism
- Pyrrolidines -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Receptor, Endothelin A
- Sodium Chloride
- Spin Labels
- Superoxides -- metabolism
- Vasodilation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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