Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate. [electronic resource]
Producer: 20040105Description: 42710-6 p. digitalISSN:- 0021-9258
- Adenosine Triphosphate -- pharmacology
- Anti-HIV Agents -- pharmacology
- Dideoxynucleotides
- Diphosphates -- pharmacology
- Drug Resistance, Viral
- Drug Synergism
- Drug Therapy, Combination
- HIV Reverse Transcriptase -- drug effects
- Humans
- Mutation, Missense
- Nevirapine -- pharmacology
- Phosphorylation -- drug effects
- Protein Subunits -- genetics
- Reverse Transcriptase Inhibitors -- pharmacology
- Thymine Nucleotides -- pharmacology
- Zidovudine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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