Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. [electronic resource]
Producer: 20031203Description: 41355-66 p. digitalISSN:- 0021-9258
- Active Transport, Cell Nucleus
- Blotting, Western
- Breast Neoplasms -- metabolism
- Cell Cycle Proteins -- biosynthesis
- Cell Division
- Cell Line, Tumor
- Cell Nucleus -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27
- Cytoplasm -- metabolism
- Down-Regulation
- Enzyme Activation
- Estrogens -- metabolism
- Fatty Acids, Unsaturated -- pharmacology
- Flow Cytometry
- G1 Phase
- Gene Expression Regulation, Enzymologic
- Genetic Vectors
- Humans
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases -- metabolism
- Models, Biological
- Mutation
- Oligonucleotides, Antisense -- pharmacology
- Phosphorylation
- S-Phase Kinase-Associated Proteins -- metabolism
- Signal Transduction
- Time Factors
- Transfection
- Tumor Suppressor Proteins -- biosynthesis
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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