Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. [electronic resource]
Producer: 20031212Description: 609-18 p. digitalISSN:- 1074-5521
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Nucleus -- drug effects
- Cyclic AMP -- analogs & derivatives
- Cytochromes c -- metabolism
- Cytosol -- drug effects
- Fluorescent Dyes
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, bcl-2 -- genetics
- Glutathione -- metabolism
- Image Processing, Computer-Assisted
- Immunoassay
- Leukemia, Promyelocytic, Acute -- metabolism
- Mice
- Mitochondria -- drug effects
- Subcellular Fractions -- drug effects
- Sulfides -- pharmacology
- Thionucleotides -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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