Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis. [electronic resource]
Producer: 20040423Description: 641-9 p. digitalISSN:- 1535-7163
- Antineoplastic Agents -- therapeutic use
- Apoptosis -- drug effects
- Butadienes -- pharmacology
- Carcinoma, Non-Small-Cell Lung -- metabolism
- Caspases -- metabolism
- Doxorubicin -- therapeutic use
- Drug Synergism
- Drug Therapy, Combination
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Humans
- JNK Mitogen-Activated Protein Kinases
- Lung Neoplasms -- metabolism
- MAP Kinase Kinase 4
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Nitriles -- pharmacology
- Paclitaxel -- therapeutic use
- Phosphorylation
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Kinase C -- antagonists & inhibitors
- Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Signal Transduction
- Staurosporine -- pharmacology
- Tumor Cells, Cultured -- drug effects
- X-Linked Inhibitor of Apoptosis Protein
- bcl-X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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