The DNA minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different DNA damage response pathways in human colon carcinoma HCT116 cells. [electronic resource]
Producer: 20040423Description: 651-9 p. digitalISSN:- 1535-7163
- Antineoplastic Agents, Alkylating -- pharmacology
- Apoptosis -- drug effects
- Benzofurans
- Cell Cycle -- drug effects
- Cellular Senescence -- drug effects
- Colonic Neoplasms -- metabolism
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins -- metabolism
- Cyclohexanecarboxylic Acids -- pharmacology
- Cyclohexenes
- DNA Damage
- DNA, Neoplasm -- drug effects
- Dose-Response Relationship, Drug
- Duocarmycins
- Humans
- Indoles -- pharmacology
- Signal Transduction -- drug effects
- Tumor Cells, Cultured -- drug effects
- Tumor Suppressor Protein p53 -- metabolism
- Urea -- analogs & derivatives
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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