Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase. [electronic resource]
Producer: 20030923Description: 219-24 p. digitalISSN:- 0304-3835
- Animals
- Antineoplastic Agents, Phytogenic -- pharmacology
- Biotransformation
- Blotting, Western
- Cell Survival -- drug effects
- Chromatography, High Pressure Liquid
- Dihydroxyphenylalanine -- metabolism
- Drug Design
- Escherichia coli -- enzymology
- Etoposide -- pharmacology
- Humans
- Mice
- Neuroblastoma -- drug therapy
- Plasmids
- Prodrugs -- chemical synthesis
- Substrate Specificity
- Tumor Cells, Cultured
- Tyrosine -- metabolism
- Tyrosine 3-Monooxygenase -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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