Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). [electronic resource]
Producer: 20031106Description: 38829-39 p. digitalISSN:- 0021-9258
- ADAM Proteins
- ADAM10 Protein
- ADAM17 Protein
- Acetophenones -- pharmacology
- Alternative Splicing
- Amyloid Precursor Protein Secretases
- Animals
- Benzopyrans -- pharmacology
- Blotting, Western
- COS Cells
- Cell Line
- Cell Membrane -- metabolism
- Ceramides -- metabolism
- Cholesterol -- metabolism
- Cyclodextrins -- metabolism
- Dimerization
- Dose-Response Relationship, Drug
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Fibroblasts -- metabolism
- Humans
- Interleukin-6 -- metabolism
- Lipid Metabolism
- Membrane Proteins -- metabolism
- Metalloendopeptidases -- metabolism
- Mice
- Mice, Transgenic
- Monocytes -- metabolism
- Precipitin Tests
- Protein Kinase C -- metabolism
- Protein Structure, Tertiary
- Receptors, Interleukin-6 -- metabolism
- Sphingomyelins -- metabolism
- Staurosporine -- pharmacology
- Time Factors
- Transfection
- beta-Cyclodextrins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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