Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. [electronic resource]
Producer: 20030807Description: 2973-84 p. digitalISSN:- 0022-2623
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- chemical synthesis
- Carrier Proteins -- metabolism
- Crystallography, X-Ray
- Drug Screening Assays, Antitumor
- HSP40 Heat-Shock Proteins
- Heat-Shock Proteins -- metabolism
- Humans
- Mice
- Mice, Nude
- Models, Molecular
- Neoplasm Transplantation
- Neoplasms, Experimental -- drug therapy
- Protein Prenylation
- Structure-Activity Relationship
- Transplantation, Heterologous
- Tumor Cells, Cultured
- rap1 GTP-Binding Proteins -- metabolism
- ras Proteins -- metabolism
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Publication Type: Journal Article
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