Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. [electronic resource]
Producer: 20030728Description: 3403-12 p. digitalISSN:- 0008-5472
- Angiogenesis Inducing Agents -- biosynthesis
- Angiopoietin-1
- Angiopoietin-2
- Animals
- Carcinoma -- blood supply
- Cell Line, Transformed -- drug effects
- Dactinomycin -- pharmacology
- Endothelial Growth Factors -- pharmacology
- Endothelium, Vascular -- drug effects
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Humans
- Intercellular Signaling Peptides and Proteins -- pharmacology
- Lymphokines -- pharmacology
- Membrane Glycoproteins -- biosynthesis
- Mice
- Mice, Inbred C57BL
- Models, Biological
- Neoplasm Proteins -- biosynthesis
- Neovascularization, Pathologic -- physiopathology
- Nucleic Acid Synthesis Inhibitors -- pharmacology
- Ovarian Neoplasms -- blood supply
- Paracrine Communication
- Pericytes -- pathology
- RNA, Messenger -- biosynthesis
- RNA, Neoplasm -- biosynthesis
- Receptor Protein-Tyrosine Kinases -- biosynthesis
- Receptor, TIE-2
- Recombinant Fusion Proteins -- biosynthesis
- Stromal Cells -- drug effects
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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