Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. [electronic resource]
Producer: 20030822Description: 1199-208 p. digitalISSN:- 0143-3334
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Renal Cell -- metabolism
- Caspases -- metabolism
- Curcumin -- pharmacology
- Cytochrome c Group -- metabolism
- Down-Regulation
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Free Radical Scavengers -- pharmacology
- Gene Expression Regulation, Neoplastic
- Humans
- Inhibitor of Apoptosis Proteins
- Kidney Neoplasms -- metabolism
- Mitochondria -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Serine-Threonine Kinases
- Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- RNA, Messenger -- metabolism
- Reactive Oxygen Species
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Cells, Cultured
- bcl-2-Associated X Protein
- bcl-X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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