Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. [electronic resource]
Producer: 20030618Description: 1395-404 p. digitalISSN:- 0270-9139
- Antioxidants -- pharmacology
- Arachidonic Acid -- poisoning
- Buthionine Sulfoximine -- poisoning
- Carcinoma, Hepatocellular -- pathology
- Cysteine Endopeptidases -- physiology
- Cytochrome P-450 CYP2E1 -- metabolism
- Drug Synergism
- Endopeptidases -- metabolism
- Humans
- Iron -- poisoning
- Leupeptins -- pharmacology
- Lipid Peroxides -- metabolism
- Liver Neoplasms -- pathology
- Lysosomes -- enzymology
- Membrane Potentials -- drug effects
- Mitochondria, Liver -- physiology
- Multienzyme Complexes -- antagonists & inhibitors
- Proteasome Endopeptidase Complex
- Tumor Cells, Cultured
- Tyrosine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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