Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. [electronic resource]
Producer: 20040112Description: 1858-67 p. digitalISSN:- 1078-0432
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Apoptosis -- drug effects
- Cell Division -- drug effects
- Deoxycytidine -- administration & dosage
- Dose-Response Relationship, Drug
- Endothelium, Vascular -- metabolism
- Fibroblast Growth Factor 2 -- metabolism
- Humans
- Implants, Experimental
- Interferon-alpha -- administration & dosage
- Interleukin-8 -- metabolism
- Male
- Matrix Metalloproteinase 9 -- metabolism
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Neoplasms, Experimental
- Pancreatic Neoplasms -- drug therapy
- Platelet Endothelial Cell Adhesion Molecule-1 -- metabolism
- Survival Rate
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A -- metabolism
- Gemcitabine
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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