Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. [electronic resource]
Producer: 20030814Description: 25386-94 p. digitalISSN:- 0021-9258
- Blotting, Western
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins -- pharmacology
- Cells, Cultured
- Chondrocytes -- metabolism
- Collagenases -- biosynthesis
- Culture Media, Conditioned -- pharmacology
- DNA -- metabolism
- Dose-Response Relationship, Drug
- Down-Regulation
- Fibronectins -- chemistry
- Gene Deletion
- Humans
- Insulin-Like Growth Factor I -- pharmacology
- Interleukin-1 -- chemistry
- Luciferases -- metabolism
- Matrix Metalloproteinase 13
- Models, Genetic
- Plasmids -- metabolism
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- RNA -- metabolism
- RNA, Messenger -- metabolism
- Receptor, IGF Type 1 -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Temperature
- Transfection
- Transforming Growth Factor beta
- Up-Regulation
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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