Interleukin-1 beta protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo. [electronic resource]
Producer: 20030711Description: 487-500 p. digitalISSN:- 1044-7431
- Animals
- Axotomy
- Cell Membrane -- drug effects
- Cell Survival -- drug effects
- Cells, Cultured
- Enzyme Inhibitors -- pharmacology
- Female
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1 -- metabolism
- Membrane Potentials -- drug effects
- Nerve Degeneration -- metabolism
- Neuroprotective Agents -- metabolism
- Optic Nerve -- surgery
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- drug effects
- Potassium Channels -- drug effects
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- drug effects
- Proto-Oncogene Proteins c-akt
- Rats
- Rats, Sprague-Dawley
- Receptors, Interleukin-1 -- drug effects
- Receptors, Interleukin-1 Type I
- Retinal Ganglion Cells -- cytology
- Sialoglycoproteins -- pharmacology
- Signal Transduction -- drug effects
- Sodium Channels -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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