Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. [electronic resource]
Producer: 20030324Description: 1605-11 p. digitalISSN:- 1529-2401
- Amyloid beta-Protein Precursor -- pharmacology
- Animals
- Cell Communication -- physiology
- Cells, Cultured
- Cerebral Cortex -- cytology
- Coculture Techniques
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1 -- genetics
- Lipopolysaccharides -- pharmacology
- Mice
- Microglia -- cytology
- Mitogen-Activated Protein Kinases -- metabolism
- Neurons -- cytology
- Neuroprotective Agents -- pharmacology
- Phosphorylation -- drug effects
- Rats
- Rats, Sprague-Dawley
- Sialoglycoproteins -- pharmacology
- Signal Transduction -- drug effects
- Synaptophysin -- metabolism
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
- p38 Mitogen-Activated Protein Kinases
- tau Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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