Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants. [electronic resource]
Producer: 20030403Description: 1150-63 p. digitalISSN:- 0950-9232
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Bone Neoplasms -- pathology
- Cell Cycle
- Codon -- genetics
- Computational Biology
- Cyclin-Dependent Kinase Inhibitor p16 -- chemistry
- Databases, Protein
- Evolution, Molecular
- Genes, p16
- Genes, p53
- Germ-Line Mutation
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation, Missense
- Osteosarcoma -- pathology
- Protein Conformation
- ROC Curve
- Sensitivity and Specificity
- Sequence Alignment
- Sequence Homology, Amino Acid
- Species Specificity
- Tumor Cells, Cultured
- Tumor Suppressor Protein p14ARF -- chemistry
- Tumor Suppressor Protein p53 -- chemistry
- Vertebrates -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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