Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. [electronic resource]
Producer: 20030319Description: 322-9 p. digitalISSN:- 1044-1549
- Allergens -- administration & dosage
- Animals
- Asthma -- prevention & control
- Benzamides -- pharmacology
- Cell Line
- Enzyme Inhibitors -- pharmacology
- Gene Expression -- drug effects
- Humans
- Hydrogen Peroxide -- pharmacology
- Inflammation -- chemically induced
- Interleukin-8 -- metabolism
- L-Lactate Dehydrogenase -- analysis
- Lung -- pathology
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NF-kappa B -- metabolism
- Nitric Oxide Synthase -- metabolism
- Ovalbumin -- administration & dosage
- Oxidants -- pharmacology
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- genetics
- Transcriptional Activation -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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