Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing. [electronic resource]
Producer: 20030703Description: 12759-68 p. digitalISSN:- 0021-9258
- Adenosine Triphosphate -- metabolism
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- Breast Neoplasms
- Caspase 8
- Caspase 9
- Caspases -- metabolism
- Cytochrome c Group -- metabolism
- Deoxyglucose -- metabolism
- Enzyme Activation
- Enzyme Precursors -- metabolism
- Female
- Glucose -- antagonists & inhibitors
- HeLa Cells
- Humans
- Kinetics
- Lymphoma
- Membrane Glycoproteins -- physiology
- Mitochondria -- physiology
- Protein Processing, Post-Translational
- Pyruvates -- metabolism
- Signal Transduction -- physiology
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha -- pharmacology
- U937 Cells
- fas Receptor -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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