2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. [electronic resource]
Producer: 20030313Description: 468-75 p. digitalISSN:- 0008-5472
- 2-Methoxyestradiol
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- Breast Neoplasms -- drug therapy
- Carrier Proteins -- biosynthesis
- Caspases -- metabolism
- Cell Division -- drug effects
- Drug Synergism
- Endothelium, Vascular -- cytology
- Enzyme Activation
- Estradiol -- analogs & derivatives
- Fas-Associated Death Domain Protein
- Female
- Humans
- Isoenzymes -- metabolism
- Membrane Glycoproteins -- pharmacology
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Receptors, Tumor Necrosis Factor -- antagonists & inhibitors
- Signal Transduction -- physiology
- TNF-Related Apoptosis-Inducing Ligand
- Transfection
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha -- pharmacology
- Up-Regulation -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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