2-[4-(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (XK469), an inhibitor of topoisomerase (Topo) IIbeta, up-regulates Topo IIalpha and enhances Topo IIalpha-mediated cytotoxicity. [electronic resource]
Producer: 20030618Description: 1321-6 p. digitalISSN:- 1535-7163
- Antigens, Neoplasm
- Blotting, Western
- Culture Media, Serum-Free
- DNA -- metabolism
- DNA Topoisomerases, Type II -- metabolism
- DNA-Binding Proteins
- Enzyme Inhibitors -- pharmacology
- Etoposide -- pharmacology
- Humans
- Immunohistochemistry
- Leukemia, Lymphocytic, Chronic, B-Cell -- blood
- Microscopy, Confocal
- Microscopy, Fluorescence
- Neoplasm Transplantation
- Protein Isoforms
- Quinoxalines -- pharmacology
- Time Factors
- Tumor Cells, Cultured
- Up-Regulation
- Waldenstrom Macroglobulinemia -- drug therapy
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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