Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens. [electronic resource]
Producer: 20030618Description: 3240-8 p. digitalISSN:- 0006-4971
- Candida albicans
- Cytoplasmic Granules -- physiology
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Flavonoids -- pharmacology
- Genes, Dominant
- Humans
- MAP Kinase Kinase 1
- MAP Kinase Signaling System -- drug effects
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Mitogen-Activated Protein Kinases -- metabolism
- Mutagenesis, Site-Directed
- Neutrophils -- physiology
- Phagocytosis -- physiology
- Phosphorylation
- Protein Processing, Post-Translational
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Recombinant Fusion Proteins -- antagonists & inhibitors
- Transduction, Genetic
- cdc42 GTP-Binding Protein -- genetics
- p21-Activated Kinases
- rac1 GTP-Binding Protein -- genetics
- rho GTP-Binding Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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