T lymphocytes are direct, aryl hydrocarbon receptor (AhR)-dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): AhR expression in both CD4+ and CD8+ T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD. [electronic resource]
Producer: 20030110Description: 146-52 p. digitalISSN:- 0041-008X
- Animals
- Body Weight
- CD4-Positive T-Lymphocytes -- drug effects
- CD8-Positive T-Lymphocytes -- drug effects
- Cytotoxicity Tests, Immunologic
- Environmental Pollutants -- toxicity
- Female
- Host vs Graft Reaction -- immunology
- Lymphocyte Activation -- drug effects
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Polychlorinated Dibenzodioxins -- toxicity
- Receptors, Aryl Hydrocarbon -- immunology
- T-Lymphocytes, Cytotoxic -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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