Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. [electronic resource]
Producer: 20030415Description: 929-35 p. digitalISSN:- 1535-7163
- Animals
- Annexin A5 -- pharmacology
- Apoptosis
- Arachidonate 12-Lipoxygenase -- metabolism
- Arachidonate 5-Lipoxygenase -- metabolism
- Arachidonic Acid -- metabolism
- Blotting, Western
- Caspase 3
- Caspase 7
- Caspase 8
- Caspase 9
- Caspases -- metabolism
- Cell Division
- Coloring Agents -- pharmacology
- Cytochrome c Group -- metabolism
- Cytosol -- metabolism
- DNA -- metabolism
- Humans
- In Situ Nick-End Labeling
- Lipoxygenase -- pharmacology
- Lipoxygenase Inhibitors -- pharmacology
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mitochondria -- metabolism
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- metabolism
- Neoplasm Transplantation
- Pancreatic Neoplasms -- enzymology
- Poly(ADP-ribose) Polymerases -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Quinolines -- pharmacology
- Substrate Specificity
- Time Factors
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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