IL-6 inhibits apoptosis of human myeloma cell line XG-7 through activation of JAK/STAT pathway and up-regulation of Mcl-1. [electronic resource]
Producer: 20030103Description: 113-6 p. digitalSubject(s):- Apoptosis -- drug effects
- DNA-Binding Proteins -- physiology
- Humans
- Interleukin-6 -- pharmacology
- Janus Kinase 2
- Mitogen-Activated Protein Kinases -- physiology
- Multiple Myeloma -- pathology
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- biosynthesis
- Phosphatidylinositol 3-Kinases -- physiology
- Protein-Tyrosine Kinases -- physiology
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- STAT1 Transcription Factor
- STAT3 Transcription Factor
- Signal Transduction
- Trans-Activators -- physiology
- Tumor Cells, Cultured
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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