Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. [electronic resource]
Producer: 20030121Description: 352-9 p. digitalISSN:- 0020-7136
- Apoptosis -- drug effects
- Benzoquinones
- Blotting, Western
- Caspase 3
- Caspase Inhibitors
- Caspases -- metabolism
- Cytochrome c Group -- metabolism
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Humans
- Lactams, Macrocyclic
- MAP Kinase Signaling System
- Mitochondria -- physiology
- Neuroblastoma -- metabolism
- Poly(ADP-ribose) Polymerases -- metabolism
- Precipitin Tests
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-raf -- metabolism
- Quinones -- pharmacology
- Signal Transduction -- physiology
- Tumor Cells, Cultured -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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